- De André Bunce originally wanted to play a role in the film, but he had a heated argument with his aunt's boyfriend at a family celebration dinner and stabbed the other party to death. He was eventually sentenced to 11 years in prison.
- Before selling the script, Antwone Fisher completed 41 drafts.
- Producer Black wanted Denzel Hayes Washington Jr. to play the psychiatrist Jerome, and what Black didn't expect was that Washington not only wanted to star, but also wanted to make the film his directorial debut.
- The two became friends while Derek Luke was writing the script for Fischer, but Luke wanted to get the role, but instead of turning to Fischer, he persuaded a friend of a friend to let him participate in an interview.
- The U.S. Navy provided great support for the filming of the film. In addition to opening the three bases in San Diego to the crew, it also authorized the cast and crew to film on the amphibious assault ship USS Bellowwood.
- To ensure the authenticity of the scene, all the extras who play the navy in the film are from the naval base, and some of them are officers who are off duty .
Antwone Fisher behind the scenes gags
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Jerome Davenport: "Regard without ill-will despite an offense." That's Webster's definition of forgiveness.
Antwone Fisher: Why do I have to forgive?
Jerome Davenport: So you can get on with your life.
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Antwone Fisher: Where's your wife?
Jerome Davenport: She couldn't make it. Sends along her congratulations. A small gift for you.
[hands Antwone a book]
Antwone Fisher: [reads book cover] The Philosophy and Opinions of Marcus Garvey. Thank you sir.
Jerome Davenport: You're welcome.