- The film was shot in the hometown of director Michael Lemo, Melbourne, where the prosperous theater stage provided convenient conditions for the crew to find supporting actors.
- The rock concert in the climax of the film was filmed in an abandoned quarry in Melbourne. The crew recruited 3,000 extras through local newspapers and radio.
- Tom Cruise had refused to continue to play Leista in the film.
- Wes Bentley refused to star in the film.
- The blood in Queen of the Damned Akasa's mouth was actually cherry juice.
- Josh Harnett was expected to play Leista in the film.
- In the film, Stuart Townsend, who plays Leista, has the same name as the character in the original author Annie Rice’s other novel "The Witching Hour". Stuart Townsend is very grateful to Anne Rice for writing him into the new book, and Annie Rice told him that the book was completed 11 years ago.
Queen of the Damned behind the scenes gags
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Lestat: [meeting for the first time in 200 years] So, after all this time, what's the occasion?
Marius: You've just become very hard to avoid these days, at least in conversation. What are you trying to prove Lestat?
Lestat: Oh please, it's a little too late to come over all paternal now Marius. Two-hundred years and not a word from you.
Marius: You almost cost me everything, and now you've done it again. This isn't the time to settle old scores.
Lestat: Vampires don't settle old scores, we harbor them.
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Lestat: [after sensing Akasha has awoken] Akasha!
Marius: Arisen. She has taken the King's blood; absorbed his power.
Lestat: Good. Let her come.
Marius: Cancel the concert.
Lestat: Never.
Marius: You're no match for her Lestat, you're not a god. We were once mortals, too; it is our heritage we protect.
Lestat: Such reverence for mortals. Then you should have left me as one.