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The movie was almost entirely shot with a handheld camera.
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The films were shot in chronological order, although in the final editing process, they were not in chronological order.
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Paul and Christina were in the restaurant. The poem he quoted from a Venezuelan poet was La Tierra Giró para Acercarnos, and the author's name was Eugenio Montejo.
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There was a scene where Jack Jordan wanted to hang himself. An overweight prisoner rescued him. He has a large tattoo on his chest with Maria Eladia written on it. This is the person Alejandro González who the film is going to contribute to. Name of his wife.
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Naomi Watts agreed to star in the film before reading the script.
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Paul found a picture of Christina and her husband in a book. He looked at the name of the book is "Cruising Paradise," by playwright Sam Shepard, which has 40 stories of loneliness and failure.
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The Spanish at the end of the film is dedicated to María Eladia, pues cuando ardió la pérdida, reverdecieron sus maizales, which translates as when they lose their burning and their cornfields will grow green again.
21 Grams behind the scenes gags
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Reverend John: Jesus didn't come to free us from pain. He came to give us the strength to bear it.
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[last lines]
Paul Rivers: How many lives do we live? How many times do we die? They say we all lose 21 grams... at the exact moment of our death. Everyone. And how much fits into 21 grams? How much is lost? When do we lose 21 grams? How much goes with them? How much is gained? How much is gained? Twenty-one grams. The weight of a stack of five nickels. The weight of a hummingbird. A chocolate bar. How much did 21 grams weigh?