-
The film was originally named "Master Mind", but because this name has been used in tabletop games and TV shows in the 1970s and the copyright of the film name has been registered, it has been changed to "Oobermind".
-
Both Ben Stiller and Robert Downey Jr. were interested in the dubbing of the Megamind character of the film, but due to schedule conflicts, they did not appear in the end.
-
The blue skin of the protagonist of the villain in the film is a tribute to the superhero spoof "Freakazoid" produced by Stephen Spielberg in 1995.
Megamind behind the scenes gags
-
Megamind: [pulls out dehydration gun on the crowd gathering around him to congratulate him for defeating Titan] Get back, you savages!
Roxanne Ritchi: Sorry, sorry! He's just not used to positive feedback.
-
Megamind: [disguised as Bernard] Roxanne...?
Roxanne Ritchi: Yes?
Megamind: Say I wasn't so normal... Say I was bald and had the complexion of a popular primary color - in a random, non-specific example... Would you still enjoy my company?
Roxanne Ritchi: Of course! You don't judge a book by its cover or a person by the outside.
Megamind: Oh! That's a relief to hear!
Roxanne Ritchi: You judge them by their actions.
Megamind: ...Well that seems kinda petty, don't you think?