- Nicole Kidman was the first candidate for Mrs. Smith, and Catherine Zeta-Jones was also the candidate. Before the filming started, the crew considered that if Brad Pitt could not appear in the film, he would ask Johnny Depp or Will Smith to replace him. It is said that when Nicole Kidman gave up acting, Brad Pitt once left the crew, and did not return to the crew until Angelina Jolie signed.
- In order to meet the PG-13 level standard, an explicit sex scene between Brad Pitt and Angelina Jolie had to be cut.
- Cate Blanchett and Gwen Stephanie were also candidates to play Mrs. Smith.
- The script of the film has been changed 50 times.
- Brad Pitt left for three months to star in "The Twelve Arhats" during the filming of the film.
- Some of the screens in the trailer did not appear in the movie.
- Angela Bessett once played Smith's boss in the film, but her scene was later cut, but her voice still appears in the film.
- Aishwarya Rai was also a candidate to play Mrs. Smith, and she refused to play because of a conflict in filming time.
Mr. & Mrs. Smith behind the scenes gags
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John Smith: I never went to MIT. Notre Dame. Art history major.
Jane Smith: Art?
John Smith: History! It's reputable.
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John Smith: I realise you witnessed the Mrs. and I working through a few domestic issues. That's regrettable but don't take that to be a sign of weakness, that would be a mistake on your part.
[Jane is drumming her fingers impatiently]
John Smith: Honey!
Jane Smith: Wrap it up.
John Smith: Maybe it's not such a good idea to undermine me in front of the hostage - sends a mixed message.
Jane Smith: Sorry.
John Smith: Girls. Where was I?
Benjamin: Mistake on your part.
John Smith: Shut up.