- The film is based on the real experience of actor George Hamilton.
- Director Richard Loncraine participated in the performance and singing of the theme song of the film.
- Mark Isham, who composed the film, wrote a theme music called "My One and Only" for the actor Dunn. Director Richard Loncraine liked it very much, so he changed the name into the film's title.
- The film has the words "Dedicated to Maeve Griffin" written in the subtitles, because Maeve Griffin was involved in the preparation of the film, but he died in 2007 .
My One and Only behind the scenes gags
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Bill Massey: As a man, there's only one thing you need to know about a woman.
George Devereaux: What's that?
Bill Massey: They're never the right temperature.
George Devereaux: No?
Bill Massey: Something to do with their plumbing. Reproduction. Whatever reason, most of the time... they're either too hot or too cold. Mostly too cold. So what you have to do... is carry a sweater or a jacket or something with you at all times. Something you can keep in the trunk of your car... or in your closet at work... for when their thermostat gets messed up.
George Devereaux: What else?
Bill Massey: That's it. Once you've got that covered... there's nothing else you need to know about a woman.
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Paula: Have you ever seen breasts?
George Devereaux: Sure... one.
Paula: You saw one breast?
George Devereaux: No, I meant once. I saw some once.
Paula: Some?
George Devereaux: Two. I saw two, once...
Paula: You wanna see mine?
George Devereaux: Who? Me? Now?
Paula: Ready?
George Devereaux: Okay. Sure, yeah.
Paula: How do they look?
George Devereaux: Alright! Good, fine. Of course I don't have much to compare them to...